Oregon Health & Science University
Cognitive function studied, role of circulating androgen levels defined
Published in Medicine and Law Weekly, October 28th, 2005
"Compared with apoE2 and E3, apoE4 increases the risk of cognitive impairments and of developing Alzheimer disease (AD). ApoE4 interacts with female sex, further increasing AD risk.
"Previously, we showed that female Apoe(-/-) mice are more susceptible to apoE4-induced cognitive deficits than male mice. Androgens protect against these deficits and apoE4 male mice are more sensitive to acute blockade of androgen receptors than apoE3 male mice," wrote T. Pfankuch and colleagues, Oregon Health & Science University.
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