Universite Claude Bernard Lyon 1

HSV-1-derived vectors for gene transfer and gene therapy are reviewed

Published in Medicine and Law Weekly, December 9th, 2005

Researchers review HSV-1-derived recombinant and amplicon vectors for gene transfer and gene therapy in a recent issue of Current Gene Therapy.

"Herpes simplex virus type 1(HSV-1) is a major human pathogen whose lifestyle is based on a long-term dual interaction with the infected host characterized by the existence of lytic and latent infections. Although in most cell types infection with HSV-1 will induce toxic effects ending in the death of the infected cells, the very deep knowledge we possess on the genetics and molecular biology of HSV-1 has permitted the deletion of most toxic genes and the development of non-pathogenic HSV-1-based vectors for gene...

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Source: Medicine and Law Weekly (2005-12-09)

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