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Hannover Medical School

T cell antigen-recognition sites found in patients with acquired aplastic anemia

Published in Medicine and Law Weekly, December 9th, 2005

A study from Germany has chronicled antigen-recognition sites of micromanipulated T cells in patients with acquired aplastic anemia (AA).

"Acquired AA is a rare disorder characterized by pancytopenia and hypocellular bone marrow. Though experimental and clinical data suggest that AA represents a T cell-mediated disease, neither the immune response nor the nature of inciting antigen(s) have been characterized so far."

W.J. Piao and colleagues, Hannover Medical School, wrote: "The identification of a restricted T cell repertoire by PCR techniques in total lymphocyte populations supports an antigen-driven T cell response. In order to investigate the...

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