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Peking Union Medical College, Beijing

MSC transplantation could inhibit LV remodeling and improve heart function

Published in Medicine and Law Weekly, December 9th, 2005

Mesenchymal stem cell transplantation can improve heart function and reduce the expression of extracellular matrix genes.

According to a study from People's Republic of China, "Myocardial fibrosis is a major component of ventricular remodeling after myocardial infarction (MI).

"The aim of the present study was to determine the outcome of transplantation into ischemic myocardium of bone marrow derived stem cell (MSC) on left ventricular (LV) function and remodeling, and to look closely at extracellular matrix gene expression."

"MI was induced by direct ligation of the left anterior descending coronary artery in rats, followed by...

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