Published in Medicine and Law Weekly, December 16th, 2005
Study 1: PI 3-K and MAPK pathways regulate pro- and anti-inflammatory cytokines by the PPD antigen of Mycobacterium tuberculosis.
"Here we investigated the role of the phosphatidylinositol 3-kinase (PI 3-K) and mitogen-activated protein kinase (MAPK) pathways in the secretion of tumor necrosis factor (TNF)-alpha and interleukin (IL)-10 in human primary monocytes after stimulation with the PPD antigen of Mycobacterium tuberculosis.
"MAPK [extracellular signal-regulated kinase (ERK) 1/2 and p38] and Akt are rapidly phosphorylated...
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