University of Ibadan

Researchers' work adds to malaria body of knowledge

Published in Medicine and Law Weekly, December 30th, 2005

Malaria data are the focus of recent research from Nigeria, France and Kenya.

Study 1: Plasmodium falciparum dhfr and dhps gene polymorphisms are associated with malaria treatment failure.

"Mutations in Plasmodium falciparum dihydrofolate reductase (dhfr) and dihydropteroate synthase (dhps) genes have been used as means to predict treatment failure to sulfadoxine-pyrimethamine (SP) and for monitoring/surveillance of resistance to the drug in many areas where malaria is endemic.

"However, patients responses to treatment are significantly dependent on factors like host immunity profile of treated patients," scientists...

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Source: Medicine and Law Weekly (2005-12-30)

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