Published in Medicine and Law Weekly, May 26th, 2006
Study 1: CD10- pre-B acute lymphoblastic leukemia (ALL) was identified as a distinct high-risk subgroup of adult ALL linked to a high frequency of MLL aberrations.
According to recent research from Germany, "Immunophenotyping disclosed CD10 negativity in 70 of 2408 cases of B-lineage ALL, although other criteria followed classification of pre-B ALL (e.g., cytoplasmic immunoglobulin positivity). These blasts showed high myeloid antigen expression (60% CD65 positivity) and reacted with antibody 7.1 in 95% of the cases."
"MLL-AF4 fusion transcripts...
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