Published in Medicine and Law Weekly, May 26th, 2006
Study 1: A study from Sweden has described the use of decoy oligonucleotides as a delivery vector for targeting the Myc protein.
"One approach to investigate gene function, by silencing the activity of certain proteins, is the usage of double stranded decoy oligodeoxynucleotides (ds decoy ODNs). Decoy, in this sense, is ds ODNs bearing the consensus binding sequence for a DNA-binding protein," wrote S. Elandaloussi and colleagues, Stockholm University.
"This can be used in clinical settings to attenuate the effect of overexpressed transcription...
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