Bambino Gesu Children's Hospital, Rome

Closure of the ductus arteriosus involves synthetic smooth muscle cells positive for CD44-v6

Published in Medicine and Law Weekly, June 9th, 2006

Closure of the ductus arteriosus (DA) involves synthetic smooth muscle cells (SMCs) highly positive for CD44-v6, and patent or closed DAs are populated by CD44-v6-negative SMCs.

According to a study from Italy, "Closure of the ductus arteriosus (DA) is due to functional constriction followed by wall remodeling, with neointimal formation caused by proliferation and migration of smooth muscle cells (SMCs) from the media to subendothelium."

"CD44 is a surface cell proteoglycan family. Its isoform, CD44-v6, is only minimally expressed in SMCs in the media of normal arteries, but is highly expressed in SMCs in the intima and media of injured arteries...

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Source: Medicine and Law Weekly (2006-06-09)

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