Singapore National Cancer Center
Carcinogenesis linked to dysregulation of FAT10 expression in p53-defective cells
Published in Medicine and Law Weekly, June 9th, 2006
According to a study from Singapore, "FAT10 is a member of the ubiquitin-like modifier family of proteins and has been implicated to play important roles in antigen presentation, cytokine response, apoptosis and mitosis. We have recently demonstrated the upregulation of FAT10 gene expression in 90% of hepatocellular carcinoma patients."
"Here, we identified and characterized the promoter of the FAT10 gene to elucidate the mechanism of FAT10 gene expression," explained D.W. Zhang and colleagues, National Cancer Center. "Notably, we found that the 50...
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