University of Pennsylvania, U.S.

Mutation in tumor suppressor gene causes pancreatic islet cells to reproduce

Published in Medicine and Law Weekly, July 28th, 2006

Researchers at the University of Pennsylvania School of Medicine have found that the acute loss of a protein called menin can cause the proliferation of pancreatic islet cells, which secrete insulin to regulate blood sugar.

The menin gene (Men1) mutation in humans causes an inherited disease called Multiple Endocrine Neoplasia type 1 (MEN1). Not only could this discovery inform basic cancer biology, it also has implications for treating Type 1 diabetes. The researchers report their findings in a recent issue of Cancer Research.

MEN1 patients develop mostly benign tumors or hyperplasia (over proliferation of cells) in several endocrine organs,...

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Source: Medicine and Law Weekly (2006-07-28)

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