National Cancer Center, Tokyo, Japan

Lung adenocarcinoma risk linked to OGG1-Ser326Cys polymorphism

Published in Medicine and Law Weekly, September 8th, 2006

The risk of developing lung adenocarcinoma (ADC) could be linked to the OGG1-Ser326Cys polymorphism.

According to recent research from Japan, "ADC is the most frequent histological type of lung cancer and comprises the majority of lung cancers in non-smokers. Thus, genetic factors responsible for ADC susceptibility need to be determined to establish efficient ways of preventing the disease."

"The OGG1 gene, encoding a glycosylase for 8-hydroxyguanine, an oxidatively damaged promutagenic base, has the polymorphism Ser326Cys, and OGG1-326Cys protein was indicated to have a lower ability to prevent mutagenesis than the OGG1-326Ser protein. Case-control...

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Source: Medicine and Law Weekly (2006-09-08)

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