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Akita University, Japan
Induced acute liver injury prevented by a receptor agonist
October 13th, 2006
According to recently published research from Japan, a selective adenosine A(2A) receptor agonist, ATL-146e, prevents concanavalin A (Con A)-induced acute liver injury in mice. "Con A activates T lymphocytes and induces CD4+ T cell-mediated hepatic injury in mice. Pro-inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-alpha), interferon-gamma (IFN-gamma), and interleukin-6 (IL-6), are critical mediators in this experimental model," wrote M. Odashima and colleagues, Akita University. They continued, "Activation of 2A receptors reduces the production of various pro-inflammatory cytokines and suppresses T cell activation. A selective...
Source: Medicine & Law Weekly (2006-10-13)
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