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Abramson Pediatrics Research Center, Philadelphia, U.S.
Nephrotoxicity is caused by chloroacetaldehyde
October 13th, 2006
Chloroacetaldehyde (CAA), a metabolite of ifosfamide (IFO), is accumulated in the renal cortex and is responsible for nephrotoxicity. According to a study from the United States, "The efficacy of IFO, an antineoplastic drug, is severely limited by a high incidence of nephrotoxicity of unknown etiology. We hypothesized that inhibition of complex I (C-I) by CAA, a metabolite of IFO, is the chief cause of nephrotoxicity, and that agmatine (AGM), which we found to augment mitochondrial oxidative phosphorylation and beta-oxidation, would prevent nephrotoxicity." "Our model system was isolated mitochondria obtained from the kidney cortex of rats treated...
Source: Medicine & Law Weekly (2006-10-13)
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