Ohio State University, U.S.
Pharmacokinetics of the heteroarotinoid antitumor agent SHetA2 analyzed by HPLC
Published in Medicine and Law Weekly, October 13th, 2006
"SHetA2 {[(4-nitrophenyl)amino][2,2,4,4-tetramethylthiochroman-6-yl)aminomethane-thione], NSC 726189} is a sulfur-containing heteroarotinoid, which selectively inhibits cancer cell growth and induces apoptosis without activation of nuclear retinoic acid receptors (RARs). The objective was to develop and validate a HPLC/UV method for the determination of SHetA2, and study the pharmacokinetics of SHetA2 in the mouse," scientists writing in the journal Cancer...
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