Wistar Institute, U.S.

Trichostatin-A enhances adaptive immune responses to DNA vaccination

Published in Medicine and Law Weekly, October 20th, 2006

Trichostatin-A enhances adaptive immune responses to DNA vaccination.

According to recent research from the United States, "The efficacy of DNA vaccines to date has overall been disappointing, especially in large animal models and in humans, which might be partially explained by the chromatinization of the administered foreign DNA. Trichostatin-A (TSA) is a specific inhibitor for histone deacetylase (HDAC) and a gene expression enhancer in in vitro DNA viral infection, including herpes simplex type 1 (HSV-1) and cytomegalovirus (CMV)."

"We sought to determine if increasing antigen expression of DNA vaccines through inhibition of HDAC-induced...

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Source: Medicine and Law Weekly (2006-10-20)

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