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Smallpox

SIGA announces smallpox treatment breakthrough

Published in Medicine and Law Weekly, November 17th, 2006

SIGA Technologies, Inc. (SIGA) announced that its lead drug, SIGA-246, is the first drug ever to demonstrate 100% protection against human smallpox virus in a primate trial conducted at the federal Centers for Disease Control and Prevention (CDC).

In this study, once-daily, oral administration of SIGA-246 protected cynomolgus monkeys from smallpox disease following intravenous high dosing with smallpox virus. The drug prevented symptoms of disease whether delivered at the same time as the virus or 24 hours later, supporting the drug's use for both post-exposure prophylaxis and treatment.

SIGA-246 completely prevented lesion formation and reduced...

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