Cancer Vaccines
Data on cancer vaccines described by A.M. Dohnal et al
Published in Medicine and Law Weekly, March 27th, 2009
"Manufacturing procedures for cellular therapies are continuously improved with particular emphasis on product safety. We previously developed a dendritic cell (DC) cancer vaccine technology platform that uses clinical grade lipopolysaccharide (LPS) and interferon (IFN)-gamma for the maturation of monocyte derived DCs," scientists writing in the Journal of Cellular and Molecular Medicine report.
"DCs are frozen after 6 hrs exposure at a semi-mature stage (smDCs) retaining the capacity to secret interleukin (IL)-12 and thus support cytolytic T-cell responses, which is lost at full maturation. We compared closed systems for monocyte enrichment from leucocyte...
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