Colitis

Research on colitis reported by scientists at Erasmus University

Published in Medicine and Law Weekly, March 27th, 2009

"Tacrolimus is a potent immunomodulator that is effective in the systemic treatment of inflammatory bowel diseases (IBD). However, potential toxicity and systemic (side) effects after oral intake limit its use," scientists in Netherlands report.

"We investigated the local applicability and Safety of tacrolimus for distal colitis. Patients; with refractory left-sided colitis or proctitis were treated for 4 weeks with a daily tacrolimus 2-4 mg enema or 2 mg suppository. Safety of local tacrolimus treatment was assessed by measurement of whole blood tacrolimus trough levels by monitoring liver and kidney function and blood glucose levels. Efficacy of treatment was assessed...

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Source: Medicine and Law Weekly (2009-03-27)

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