University of Pittsburgh
Gadd45a contributes to p53 stabilization in response to DNA damage
Published in Mental Health Business Week, January 12th, 2004
"p53 is an important molecule in cellular response to DNA damage. After genotoxic stress, p53 protein stabilizes transiently and accumulates in the nucleus, where it functions as a transcription factor and upregulates multiple downstream-targeted genes, including p21(Waf1/Cip1), Gadd45a and Bax," investigators in the United States report.
"However, regulation of p53 stabilization is complex and may mainly involve post-translational modification of p53, such as phosphorylation and acetylation," wrote S.Q....
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