Toronto Western Hospital
Ondansetron treatment doesn't significantly reduce fatigue
Published in Mental Health Business Week, July 23rd, 2005
"Fatigue is common" in PBC patients, hepatologists in Canada noted. "Altered central serotonergic neurotransmission may be involved in its pathogenesis."
In a "multicenter, randomized, double-blind, placebo-controlled, crossover trial," J.J. Theal and colleagues at Toronto Western Hospital "evaluated the efficacy of ondansetron, a selective 5-HT3 receptor subtype antagonist, for treating fatigue in PBC."
"A crossover design was chosen, allowing subjects to serve as their own...
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