Published in Mental Health Business Week, July 23rd, 2005
"Familial Alzheimer disease-causing mutations in the presenilins increase production of longer pathogenic amyloid beta-peptides (Abeta(42/43)) by altering gamma-secretase activity. The mechanism underlying this effect remains unknown, although it has been proposed that heteromeric macromolecular complexes containing presenilins mediate gamma-secretase cleavage of the amyloid beta-precursor protein," wrote Y. Nakaya and colleagues, Shiga University of Medical Science.
"Using a random...
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