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Shiga University of Medical Science

Presenilin-1 studied, mutants generating long amyloid beta-peptides identified

Published in Mental Health Business Week, July 23rd, 2005

According to recently published research from Japan, random mutagenesis of presenilin-1 (PS1) identifies novel mutants exclusively generating long amyloid beta-peptides.

"Familial Alzheimer disease-causing mutations in the presenilins increase production of longer pathogenic amyloid beta-peptides (Abeta(42/43)) by altering gamma-secretase activity. The mechanism underlying this effect remains unknown, although it has been proposed that heteromeric macromolecular complexes containing presenilins mediate gamma-secretase cleavage of the amyloid beta-precursor protein," wrote Y. Nakaya and colleagues, Shiga University of Medical Science.

"Using a random...

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