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Chiba University

Brain-derived neurotrophic factor reduced in eating disorders

Published in Mental Health Business Week, July 23rd, 2005

The level of brain-derived neurotrophic factor is significantly reduced in people with eating disorders.

According to recent research from Japan, "Eating disorders, which include anorexia nervosa (AN) and bulimia nervosa (BN), are disorders characterized by abnormal patterns of weight regulation and eating behaviors, and by disturbances in attitudes and perceptions toward weight and body shape.

"Brain-derived neurotrophic factor (BDNF) plays a critical role in regulating neural survival, development, function, and plasticity in the brain. Recent findings using heterozygous BDNF (±)knock-out (reduced BDNF levels) mice have provided evidence...

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