Eli Lilly & Co.
Novel gamma-secretase inhibitor lowers amyloid beta levels
Published in Mental Health Business Week, September 3rd, 2005
"Amyloid beta (Abeta) may play a central role in the pathogenesis of Alzheimer disease," scientists in the United States explained. "A functional gamma-secretase inhibitor, LY450139, was developed that inhibits Abeta formation in whole cell assays, transgenic mice, and beagle dogs."
E. Siemers and colleagues working at Eli Lilly & Co. conducted a study "to determine the safety and tolerability of this drug, and the reduction of Abeta in plasma and cerebrospinal fluid (CSF) after multiple doses."
"Volunteer subjects (n=37) were studied using doses from...
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