Life Sciences

New findings from E. Santini and co-researchers in the area of life sciences described

Published in Mental Health Business Week, July 19th, 2008

"Extinction of conditioned fear is an active learning process involving inhibition of fear expression. It has been proposed that fear extinction potentiates neurons in the infralimbic (IL) prefrontal cortex, but the cellular mechanisms underlying this potentiation remain unknown," scientists in the United States report.

"It is also not known whether this potentiation occurs locally in IL neurons as opposed to IL afferents. To determine whether extinction enhances the intrinsic excitability of IL pyramidal neurons in layers II/III and V, we performed whole-cell patch-clamp recordings in slices from naive, conditioned, or conditioned-extinguished rats. We observed that...

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Source: Mental Health Business Week (2008-07-19)

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