Life Sciences
Reports from Vanderbilt University add new data to research in life sciences
Published in Mental Health Business Week, January 2nd, 2010
According to a study from the United States, "PGE(2) binds to PGE(2) receptors (EP1-4). The purpose of the present study was to investigate the role of the EP4 receptor in angiogenic cell behaviors of retinal Muller cells and retinal microvascular endothelial cells (RMECs) and to assess the efficacy of an EP4 antagonist in rat models of oxygen-induced retinopathy (OIR) and laser-induced choroidal neovascularization (LCNV)."
"Muller cells derived from COX-2-null mice were treated with increasing concentrations of the EP4 agonist PGE(1)-OH, and wild-type Muller cells were treated with increasing concentrations of the EP4 antagonist L-161982; VEGF production was assessed....
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