Maxygen, Inc.
5HTIA serotonin receptor agonists suppress P. falciparum growth
Published in Mental Health Law Weekly, January 12th, 2004
"To identify new leads for the treatment of Plasmodium falciparum malaria," researchers in California "screened a panel of serotonin (5-hydroxytryptamine [5HT]) receptor agonists and antagonists and determined their effects on parasite growth."
"The 5HT1A receptor agonists 8-hydroxy-N-(di-n-propyl)-aminotetralin (8-OH-DPAT), 2,5-dimethoxy-4-iodoamphetamine, and 2,5-dimethoxy-4-bromophenylethylamine inhibited the growth of P. falciparum in vitro (50% inhibitory concentrations, 0.4, 0.7, and 1.5 microM, respectively)," reported C.P. Locher and colleagues...
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