German Cancer Research Center
Neuroblastoma-derived sulfhydryl oxidase reverses resistance to apoptosis
Published in Mental Health Law Weekly, January 12th, 2004
According to a study from Germany, "in neuroblastoma cells, apoptotic programs can be activated by cytokines and cytostatic drugs. Apoptotic dysfunction confers resistance against therapeutic drugs and is a major complication for achieving optimal therapy response. Deregulated expression of the MYCN gene is a critical determinant in neuroblastoma progression, and one of the pleiotropic functions of the MYCN protein is cellular sensitization to cytokine-induced and drug-induced apoptosis."
"By using the functional approach of technical knockout (TKO), we have identified five...
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