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University of Pennsylvania

Behavioral impairments caused by anisomycin reverse with time

Published in Mental Health Law Weekly, June 19th, 2004

The behavioral impairments caused by injections of the protein synthesis inhibitor anisomycin after contextual retrieval reverse with time.

"Recent accounts of memory suggest that retrieval of a learning experience transforms that memory into a labile state that requires a period of protein synthesis to be reconsolidated into a fixed state. In this article, we show that the impairments in behavior caused by the protein synthesis inhibitor anisomycin given after retrieval are temporary and are thus not likely to reflect disruptions in a protein synthesis-dependent reconsolidation process," researchers in the United States report.

"Mice received...

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