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Natl Inst Advanced Ind Sci & Tech, Hyogo

ABCG2 transporter functionally expressed in neural stem/progenitor cells

Published in Mental Health Law Weekly, July 9th, 2005

The ABCG2 transporter is functionally expressed in neural stem/progenitor cells.

According to recent research from Japan, "We have studied the expression, localization, and function of the ABCG2 transporter, a universal stem cell marker, at the protein level in human cultured neural stem/progenitor cells (hNSPCs) using immunoblotting, immunofluorescence, and ATPase assays. Human NSPCs were isolated from human fetal brain and propagated in vitro as neurospheres."

"Both the cells in neurospheres and single cells dissociated from neurospheres showed high levels of ABCG2, and about 63% of the cells in neurospheres were ABCG2-positive, similar to the...

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