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Erasmus University Medical Center, Rotterdam

Adenosine A₁ receptor agonist GR79236 has promising postjunctional effects

"Migraine is a common neurological disorder that is associated with an increase in plasma calcitonin gene-related peptide (CGRP) levels," scientists in the Netherlands explained. "CGRP, a potent vasodilator released from the activated trigeminal sensory nerves, dilates intracranial blood vessels and transmits vascular nociception."

"Hence, inhibition of trigeminal CGRP release may prevent neurotransmission and, thereby, ameliorate migraine headache," argued U. Arulmani and colleagues at the Erasmus MC, University Medical Center in...

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