Mental Health Law Weekly
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RIKEN Brain Science Institute
ASCL1 may be associated with Parkinson disease
December 17th, 2005
According to recent research from Japan, genetic association analyses of PHOX2B and ASCL1 provides evidence for association of ASCL1 with Parkinson disease (PD). "We previously identified frequent deletion/insertion polymorphisms in the 20-Ala homopolymer stretch of PHOX2B (PMX2B), the gene for a transcription factor that plays important roles in the development of oculomotor nerves and catecholaminergic neurons and regulates the expression of both tyrosine hydroxylase and dopamine beta-hydroxylase genes." "An association was detected between gene polymorphisms and overall schizophrenia, and more specifically, schizophrenia with ocular misalignment,"...
Source: Mental Health Law Weekly (2005-12-17)
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