Mental Health Law Weekly
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University of Florida
MC3R and MC4R KO mice have altered ghrelin-induced food intake and GH secretion
December 17th, 2005
Melanocortin 3 and 4 receptor knockout mice exhibit an altered ghrelin-induced food intake and growth hormone secretion pattern. According to recent research published in the journal Peptides, "Ghrelin stimulates food intake in part by activating hypothalamic neuropeptide Y (NPY) neurons/agouti related peptide (AGRP) neurons." A.M. Shaw and colleagues working with the University of Florida examined "the role of AGRP/melanocortin signaling in ghrelin-induced food intake by studying melanocortin 3 and 4 receptor knockout (MC3R KO and MC4R KO) mice. [They] also determined whether reduced ghrelin levels and/or an altered sensitivity to the...
Source: Mental Health Law Weekly (2005-12-17)
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