Mental Health Law Weekly
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University of Ferrara
Nociceptin/orphanin FQ blockade provides neuroprotection and symptom relief in rats
December 17th, 2005
Nociceptin/orphanin FQ (N/OFQ) blockade provides neuroprotection and symptomatic relief in a rat model of Parkinson disease. The opioid-like neuropeptide N/OFQ "and its receptor (NOP) are expressed in the substantia nigra (SN), a brain area containing dopamine neurons that degenerate in Parkinson disease," neurologists in Italy explained. "Endogenous N/OFQ facilitates nigral glutamate release and inhibits nigrostriatal dopamine transmission and motor behavior," added M. Marti and colleagues at the University of Ferrara. In a report published in the Journal of Neuroscience, they presented "evidence suggesting that endogenous N/OFQ may...
Source: Mental Health Law Weekly (2005-12-17)
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