Mental Health Law Weekly
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University of Glasgow
[I-131]MIBG and topotecan combination therapy evaluated for neuroblastoma
December 17th, 2005
[I-131]MIBG and topotecan combination therapy was evaluated for neuroblastoma. "MIBG is selectively concentrated in neuroblastoma cells, and radioiodinated MIBG has been used with some success for targeted radiotherapy. However, long-term cure remains elusive, and the topoisomerase I inhibitor topotecan may improve upon existing [I-131]MIBG therapy," researchers in Scotland reported. "While synergistic killing by combinations of ionizing radiation and topoisomerase I inhibitors has been reported, there is no consensus on optimal scheduling. Furthermore, there has been no attempt to demonstrate radiopotentiation by topoisomerase I inhibitors and...
Source: Mental Health Law Weekly (2005-12-17)
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