Mental Health Law Weekly
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Stuivenberg Hospital, Antwerp
Org 25969 safely and effectively reverses rocuronium neuromuscular block in humans
December 17th, 2005
The novel agent Org 25969 safely and effectively reverses rocuronium neuromuscular block in humans. "Acetylcholinesterase inhibitors are widely used for the reversal of neuromuscular blocking agents. However, acetylcholinesterase inhibitors have several side effects and are not effective during profound block," according to anesthesiologists in Belgium. "Org 25969 is a modified gamma-cyclodextrin that encapsulates the neuromuscular blocking agent, rocuronium bromide (Esmeron/Zemuron, NV Organon, Oss, the Netherlands), forming a tightly bound complex with an association constant of approximately 107/M," explained F. Gijsenbergh and...
Source: Mental Health Law Weekly (2005-12-17)
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