Mental Health Law Weekly
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University of Castilla La Mancha, Albacete
p53 and the pro-apoptotic p53 target gene are activated during apoptosis of chromaffin cells
December 17th, 2005
A study from Spain has documented the activation of p53 and the pro-apoptotic p53 target gene PUMA during depolarization-induced apoptosis of chromaffin cells. "The pathogenesis of non-glutamatergic, depolarization-induced cell death is still enigmatic. Recently, we have shown that veratridine induces apoptosis in chromaffin cells, and we have demonstrated protective effects of antioxidants in this system, suggesting a role for Na+ channels and oxidative stress in depolarization-induced cell death," wrote M. Gomez-Lazaro and colleagues, University of Castilla La Mancha. "We examined the possible contribution of p53, a transcription factor...
Source: Mental Health Law Weekly (2005-12-17)
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