Mental Health Law Weekly
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U.S. National Institute of Environmental Health Sciences
Thrombospondin-1 helps cyclooxygenase inhibitors fight cancer invasion
December 17th, 2005
Thrombospondin-1 (TSP-1) helps cyclooxygenase (COX) inhibitors fight cancer invasion. "COX inhibitors have antitumorigenic activity and increase the expression of the early growth response gene Egr-1, a tumor suppressor gene and transcription factor. In this study, we have investigated the gene regulatory and anti-invasive activity of two traditional nonsteroidal anti-inflammatory drugs (NSAID), sulindac sulfide and indomethacin," investigators in the United States report. "These compounds inhibited tumor cell invasion and induced Egr-1 expression in lung adenocarcinoma A549 cells. Overexpression of Egr-1 reduced cellular invasion in the Matrigel...
Source: Mental Health Law Weekly (2005-12-17)
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