Reports summarize pharmacodynamics study results from D.R. Mould and co-researchers

New research, 'Pharmacokinetics and pharmacodynamics of monoclonal antibodies: concepts and lessons for drug development,' is the subject of a report. According to a study from the United States, "Monoclonal antibodies (mAbs) have complex pharmacology; pharmacokinetics and pharmacodynamics depend on mAb structure and target antigen. mAbs targeting soluble antigens often exhibit linear pharmacokinetic behavior, whereas mAbs targeting cell surface antigens frequently exhibit nonlinear behavior due to receptor-mediated clearance. Where nonlinear kinetics exist, clearance can change due to receptor loss following repeated dosing and/or disease severity. mAb pharmacodynamics are often indirect,...

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