Central Nervous System

Research results from National Institutes of Health update understanding of central nervous system

Published in Mental Health Law Weekly, January 30th, 2010

According to a study from the United States, "Prenatal exposure to cocaine causes cytoarchitectural alterations in the developing neocortex. Previously, we reported that cocaine inhibits neural progenitor cell proliferation through oxidative endoplasmic reticulum stress and consequent down-regulation of cyclin A, whereas cyclin A expression was increased in astrocytes."

"In the present study, cell type-specific responses to cocaine were further explored. Gene expression profiles were examined in 5 types of cells obtained from the human fetal cerebral cortex at 20 weeks gestation. Cells were treated with 100 mc M cocaine in vitro for 24 hours, followed by gene expression...

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Source: Mental Health Law Weekly (2010-01-30)

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