Mental Health Weekly Digest
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Antipsychotic Drugs
Quetiapine, iloperidone, melperone selectively increase dopamine/acetylcholine
February 10th, 2003
According to recent research from the United States, "preferential increases in both cortical dopamine (DA) and acetylcholine (ACh) release have been proposed to distinguish the atypical antipsychotic drugs (APDs) clozapine, olanzapine, risperidone, and ziprasidone from typical APDs such as haloperidol. Although only clozapine and ziprasidone are directly acting 5-HT1A agonists; WAY100635, a selective 5-HT1A antagonist, partially attenuates these atypical APD induced increases in cortical DA release that may be due to combined blockade. However, WAY100635 does not attenuate clozapine induced cortical ACh release. "The present study determined whether quetiapine,...
Source: Mental Health Weekly Digest (2003-02-10)
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