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Bipolar Disorder

Brain area that regulates emotions is smaller in manic-depressive people

Published in Mental Health Weekly Digest, January 12th, 2004

A brain-scanning study of adolescents and adults with bipolar disorder shows significant decrease in size in the amygdala, a brain structure that governs emotions, a Yale School of Medicine researcher has found.

These findings suggest that amygdala volume deficit is an early feature of bipolar disorder that is present by adolescence and persists into adulthood, said principal investigator Hilary Blumberg, MD, assistant professor of psychiatry. Bipolar disorder is also known as manic-depressive illness.

The researchers measured the almond-shaped amygdala using magnetic resonance imaging. In addition to the reduced size of the amygdala in adults, they...

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