Mental Health Weekly Digest
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Endocrinology
Hypothalamic glutamate decarboxylase expression cuts rodent feeding behavior
June 28th, 2004
Hypothalamic glutamate decarboxylase expression cuts rodent feeding behavior. "In vivo gene transfer of glutamate decarboxylase (GAD) has been explored as a means of inducing or increasing the production of the inhibitory amino-acid neurotransmitter, GABA. This strategy has been applied to neuroprotection, seizure prevention, and neuromodulation. In the present experiment, adeno-associated virus (AAV)2 was used to transfer the genes for green fluorescence protein (GFP) and GAD65 into the lateral nucleus of the rat hypothalamus," scientists in the United States report. "Microinjection of 500 nl of AAV2 resulted in transduction of a 0.25±0.04...
Source: Mental Health Weekly Digest (2004-06-28)
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