Mental Health Weekly Digest
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Immunology
Naloxone-induced morphine withdrawal increases thalamic mast cells
June 28th, 2004
Naloxone-induced morphine withdrawal increases the number of thalamic mast cells. According to a study from the United States, "Naloxone-induced jumping in morphine-dependent mice is inhibited by cromolyn, a mast cell stabilizer, suggesting that this characteristic withdrawal behavior results from degranulation of mast cells. Because withdrawal is considered as a central phenomenon, degranulation of mast cells located within the CNS may influcence aspects of opioid withdrawal. The present study evaluates histologically whether naloxone injected into opioid dependent mice induces degranulation of mast cells." "Seventy-two hours after subcutaneous...
Source: Mental Health Weekly Digest (2004-06-28)
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