Mental Health Weekly Digest
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Mental Health
Neocortical transcriptome changes occur during embryogenesis or adulthood
August 28th, 2006
A recent study from the United States has documented that the specificity and timing of neocortical transcriptome changes in response to brain-derived neurotrophic factor (BDNF) gene ablation during embryogenesis or adulthood. "BDNF has been reported to be critical for the development of cortical inhibitory neurons. However, the effect of BDNF on the expression of transcripts whose protein products are involved in gamma amino butric acid (GABA) neurotransmission has not been assessed," wrote C. Glorioso and colleagues, University of Pittsburgh. "In this study, gene expression profiling using oligonucleotide microarrays was performed in prefrontal...
Source: Mental Health Weekly Digest (2006-08-28)
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