Mental Health Weekly Digest
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Addiction Medicine
Thienorphine is potent long-acting partial opioid agonist
August 28th, 2006
Thienorphine is a potent long-acting partial opioid agonist. According to recent research published in the Journal of Pharmacology and Experimental Therapeutics, "A strategy in the development of new treatment for opioid addiction is to find partial opioid agonists with properties of long duration of action and high oral bioavailability. In a search for such compounds, thienorphine, a novel analog of buprenorphine, was synthesized." "We report that, like buprenorphine, thienorphine bound potently and nonselectively to mu-, delta-, and kappa-opioid receptors stably expressed in CHO (Chinese hamster ovary) cells and behaved as a partial agonist...
Source: Mental Health Weekly Digest (2006-08-28)
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