Mental Health Weekly Digest
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Alzheimer Disease
Alzheimer disease functional gene polymorphisms studied
August 28th, 2006
A recent study from Columbia has reported on an analysis of functional polymorphisms in three synaptic plasticity-related genes (BDNF, COMT AND UCHL1) in Alzheimer disease (AD). "In recent years, it has been proposed that synaptic dysfunction may be an important etiological factor for AD. This hypothesis has important implications for the analysis of AD genetic-risk in case-control studies. "In the present work, we analyzed common functional polymorphisms in three synaptic plasticity-related genes (brain-derived neurotrophic factor, BDNF Va166Met; catechol-O-methyl transferase, COMT Va1158; ubiquitin carboxyl-terminal hydroxylase, UCHL1 S1 8Y) in a...
Source: Mental Health Weekly Digest (2006-08-28)
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