Alzheimer Disease

Research from Niigata University provides new data on Alzheimer disease

Published in Mental Health Weekly Digest, March 3rd, 2008

"Mutations in the PSEN1 gene encoding presenilin 1 ( PS1) are linked to a vast majority of pedigrees with early- onset, autosomal dominant forms of familial Alzheimer's disease ( FAD). Lewy body ( LB) pathology is frequently found in the brains of FAD patients harboring PSEN1 mutations," scientists in Niigata, Japan report.

"We recently reported on a novel PS1 mutation with the deletion of threonine at codon 440 (Delta T440) in a familial case diagnosed as having the neocortical type of dementia with LBs ( DLB) and variant AD. In this report, we investigated the possible involvement of PS1 Delta T440 mutation in aberrant alpha-synuclein accumulation. We established cell...

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Source: Mental Health Weekly Digest (2008-03-03)

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