Life Sciences

Study results from Mount Sinai School of Medicine provide new insights into life sciences

Published in Mental Health Weekly Digest, March 17th, 2008

Investigators publish new data in the report 'Synergistic toxicity induced by prolonged glutathione depletion and inhibition of nuclear factor-kappaB signaling in liver cells.' "TNF-alpha, GSH depletion and CYP2E1 are factors that play an important role in alcoholic liver disease. Activation of NF-kappaB prevents hepatocyte damage caused by TNF-alpha," investigators in the United States report.

"This work describes the effect of NF-kappaB inhibition on toxicities caused by GSH depletion or arachidonic acid (AA) treatment in liver cells, and evaluates the possible influence of CYP2E1 overexpression. Cells were exposed to the NF-kappaB inhibitor BAY11-7082, in the absence...

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Source: Mental Health Weekly Digest (2008-03-17)

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