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Addiction Medicine

New addiction medicine study findings recently were reported by researchers at Kyoto University

Published in Mental Health Weekly Digest, December 1st, 2008

According to a study from Kyoto, Japan, "Several lines of evidence suggest the involvement of the raphe-serotonergic neurons in addiction to psychostimulants and some recreational drugs. In this study, we established rat organotypic mesencephalic slice cultures containing the raphe nuclei and examined the effects of sustained exposure to 3,4-methylenedioxymethamphetamine (MDMA) and methamphetamine (METH)."

"Immunostaining for tryptophan hydroxylase (TPH) studies revealed that serotonergic neurons were abundant in the slice cultures. Sustained exposure to MDMA and METH (1-1000 mc M) for 4 days had little effect on the serotonin tissue content, [H-3]citalopram binding, or...

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